These electrical and magnetic properties indicate that the ferromagnetism of the MnxGe1-x: H films is intrinsic ferromagnetism mediated by the spin-polarized hole carriers. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3573781]“
“The potential protective effect of (+/-)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester (II) was assessed against hydrogen peroxide (H2O2)-cytotoxicity in rat pancreatic INS-1E AZD5582 beta cells and compared with the effect of the related pyridoindole,
stobadine (I), a promising indole-type reference antioxidant. Only pre-treatment with the compound (II) led to a significant preservation of the metabolic and secretory functions of the cells exposed to H2O2.
The caspase-9 and -3 activities, as well as the early apoptotic changes of plasma membrane, were suppressed in the cells pre-incubated with both of compounds tested. However, only pyridoindole (II) inhibited profoundly the time-delayed apoptotic changes, as demonstrated by ethidium bromide/acridine orange staining assay. These efficacies were in line with the intracellular oxidant-normalizing effects, involving most likely both
direct SB-715992 scavenging mechanism and the modulatory effect on catalase, as H2O2-detoxifying enzyme.
These results suggest that pyridoindole (II) characterized by enhanced intrinsic antioxidant efficiency, may protect beta cells against cytotoxic effects of H2O2, involved in the development of both type 1 and type 2 diabetes.”
“The fracture criterion
of metallic glass (MG) is still PF 00299804 under debate so far. On the issue of describing the normal stress effect on the tensile fracture behaviors of MGs, there are two fracture criteria: the Mohr-Coulomb (M-C) criterion and the Ellipse criterion. In this study, the normal stress acting on the tensile fracture planes was controlled and varied in a wide range by introducing inclined notches with different inclination angles to a series of Zr-based MG specimens. Based on the experimental results, both the Ellipse criterion and the M-C criterion are compared and analyzed. The experimental results reveal that the Ellipse criterion gives a better prediction than the M-C criterion for the tensile fracture behavior of the investigated Zr-based MG in a wide normal stress range. Moreover, the pressure and normal stress effects were separately considered and some other criteria were further discussed. It is found that under tensile loading, the pressure effect is weak while the normal stress effect is strong. Combined with previously reported results for a variety of MGs, the Ellipse criterion is found to have the capability to describe all the different contributions of the normal stress effect and thus may be suitable as a unified tensile fracture criterion for all MGs with different fracture behaviors. (C) 2011 American Institute of Physics. [doi:10.1063/1.