This was associated with a decrease in early GLP-1 secretion, in contrast to that observed in non-surgical subjects. This finding could be explained by the reduction of glucose load in the jejunum produced by the alpha-glucosidase inhibition, which is the main stimulus for GLP-1 secretion.”
“OBJECTIVES: Low cardiac output syndrome is common after paediatric cardiac
surgery. Previous studies suggested that hydrocortisone administration may improve haemodynamic stability in case of resistant low cardiac output syndrome in critically ill children. This study was set up to test the hypothesis selleck that the effects of hydrocortisone on haemodynamics in children with low cardiac output syndrome depend on the presence of (relative) adrenal insufficiency.
METHODS: A retrospective study was done on paediatric patients who received hydrocortisone when diagnosed with resistant low cardiac output syndrome after paediatric cardiac surgery in the period from 1 November 2005 to 31 December 2008. We studied the difference in effects
of treatment with hydrocortisone administration between patients with adrenal insufficiency EX 527 datasheet defined as an exploratory cut-off value of total cortisol of < 100 nmol/l and patients with a serum total cortisol of >= 100 nmol/l.
RESULTS: A total of 62 of patients were enrolled, meeting the inclusion criteria for low cardiac output syndrome. Thirty-two patients were assigned to Group 1 (< 100 nmol/l) and 30 were assigned to Group 2 (>= 100 nmol/l). Haemodynamics improved after hydrocortisone administration, with an OICR-9429 concentration increase in blood pressure, a decrease in administered vasopressors and inotropic drugs, an increase in urine production and a decrease in plasma lactate concentrations.
CONCLUSIONS: The effects of treatment with hydrocortisone in children with low cardiac output after cardiac surgery was similar in patients with a low baseline serum cortisol concentration and those with normal baseline cortisol levels. A cortisol value using an
exploratory cut-off value of 100 nmol/l for adrenal insufficiency should not be used as a criterion to treat these patients with hydrocortisone.”
“Globe artichoke [Cynara cardunculus var. scolynuts (L.) Fiori] is a perennial herbaceous plant cultivated principally in the Mediterranean basin for its immature inflorescences (heads). Among the other possible uses of this species, biomass production may be considered. In this work, 17 Italian globe artichoke genotypes have been studied for two years in the field in order to evaluate their biomass production for pharmaceutical active compound extraction and to select the genotypes more suitable for this purpose. Biomass has been characterized agro-morphologically, using five of the UPOV (International Union for the Protection of New Varieties of Plants) descriptors (i.e.