Recent studies revealed the important role of Wnt signaling in maintaining carbohydrate and lipid homeostasis. Activation of the Frizzled/LRP receptor complex leads to increase in the activity of transcription factors and nuclear receptors that regulate expression of genes involved in lipid utilization (PPAR delta, RAR, LXR) and inhibits adipogenesis. The Wnt signaling pathway is also involved in the regulation of gluconeogenesis and glycolysis. This review summarizes the current state of knowledge about mechanisms that regulate canonical Wnt signaling and its role in cell metabolism regulation.”
“OBJECTIVE: To evaluate the health-related quality of life (HRQoL) and to identify physiological and

psychosocial variables predicting the HRQoL among Korean people with chronic respiratory

disease (CRD).

DESIGN: A cross-sectional correlation study was done with a convenience sample LBH589 ic50 of 112 participants (aged 62.9 +/- 1.2.9 years, forced expiratory check details volume in 1 second [FEV(1)%] predicted = 52.3 +/- 20.2) from the out-patient respiratory clinic of a large university hospital in Korea. HRQoL was measured using the chronic respiratory disease questionnaire (CRDQ). To identify the influencing factors, physiological (lung function, dyspnoea, symptom experience and exercise performance) and psychological (mood states and self-efficacy) variables were examined using path analysis.

RESULTS: Participants had a moderate level of HRQoL, with the lowest scores in CRDQ-fatigue (3.3 +/- 1.3) and the highest in CRDQ-mastery (5.2 +/- 1.0). Anxiety and a depressive mood state (-0.38) exerted the highest influence on HRQoL, followed by self-efficacy (0.36), dyspnoea (-0.27), exercise performance (0.22) and respiratory symptoms (-0.17).

CONCLUSION: Our findings emphasise the importance of a multidimensional therapeutic approach to improve HRQoL. Comprehensive interventions, including enhanced exercise performance, self-efficacy and symptom management, should be considered to improve HRQoL in Koreans

with CRD.”
“Purpose Up until now there were no specific questionnaire translated into Spanish for evaluating urinary disorder specific health-related quality of life (HRQoL) associated INCB024360 with multiple sclerosis (MS). Qualiveen is recommended by the European Association of Urology guidelines as a tool for evaluating neurogenic lower urinary tract dysfunction. The objective was to translate the Qualiveen into Spanish, adapt it cross-culturally and validate it against the currently available tools. Materials and Methods: A bidirectional translation of Qualiveen was undertaken by professional translators. One hundred two Spanish MS patients were sent the Qualiveen and the ICIQ-SF questionnaires twice within a month. The questionnaires were sent and received by mail and reviewed when the patients came for the scheduled visit. Results: Eighty-one patients participated.