4 ± 7.0 and 54.8 ± 7.6 years, respectively (p = 0.481)), BI at onset (mean score ± SD: 38.6 ± 37.6 and 42.8 ± 40.0, respectively (p = 0.382)), BI at initial rehabilitation (mean score ± SD: 55.3 ± 36.7 and 54.2 ± 39.0, check details respectively (p = 0.813)), and BI at discharge (mean score ± SD:

89.4 ± 21.7 and 90.1 ± 20.1, respectively (p = 0.774)). Among those who were followed-up, 128 patients (51 %: 51.5 % of men, 50 % of women) reported a successful return to work within 574 days after stroke onset (Fig. 1). Table 1 Basic characteristics of subjects studied (n = 250) Variables Number of patients Returned to work (%) p Demographic factors  Gender     0.874   Male 202 51.5     Female 48 50    Education     0.03   College 44 70.5     Junior college 18 55.6     High school 123 49.6     Less than high school 34 38.2   Diagnostic factors  Diagnosis     0.017   Cerebral hemorrhage 90 38.9     Cerebral Infarction 133 57.1     Subarachnoid hemorrhage 23 60.9

   Side of hemiplegia     0.007   Right 124 42.7     Left 85 56.5     Bilateral 7 28.6     None 28 75    Weakness in hemiplegic upper extremity     <0.001   Normal or mild 162 60.5     Moderate 45 40     Severe 39 23.1    Weakness in hemiplegic Daporinad solubility dmso lower extremity     <0.001   Normal or mild 188 60.1     Moderate 45 26.7     Severe 12 0    Dysphasia     <0.001   No 227 54.6     Yes 18 11.1    Dysarthria     0.035   No 189 55     Yes 57 38.6    Aphasia     <0.001   No 201 57.7     Yes 44 22.7    Visuospatial neglect     <0.001   No 216 56     Yes 29 13.8    Apraxia     <0.001   No 228 54.4     Yes 17 5.9    Shoulder-hand syndrome     <0.001   No 229 54.6     Yes 17 5.9    Shoulder subluxation

    <0.001   No 218 56.4     Yes 28 10.7    Spasticity     0.003   No 217 54.8     Yes 29 24.1    Depression     0.808   No 228 50.9     Yes 18 55.6    Attention dysfunction     <0.001   No 197 58.4     Yes 48 22.9    Memory dysfunction     <0.001   No 201 57.7     Yes 43 20.9    Intelligence dysfunction     0.001   No 209 56     Yes 35 25.7    Fatigability     0.002   No 182 57.1     Yes 63 34.9   Functional factors  mRS* at initial rehabilitation     <0.001   0 3 33.3     1 26 69.2     2 42 71.4     3 36 58.3     4 71 49.3     5 68 29.4    mRS* at discharge     <0.001   0 24 62.5     1 99 71.7     2 63 49.2     3 32 18.8     4 22 13.6 Loperamide     5 5 0    Walking ability     <0.001   Independent 190 61.6     Assisted 55 14.5   Treatment factor  Surgical operation     0.331   Yes 47 44.7     No 195 53.3   Occupational factors  Job type     0.013   Blue collar 156 44.9     White collar 94 67.1    Work position     0.001   Manager 36 47.2     Head of department 44 72.7     Regular employee 115 52.2     Other 41 29.3    Full time or part time     0.127   Full time 198 55.1     Part time 35 37.1    Mental stress at work     0.011   No 167 45.5     Yes 83 62.7    Approach from physician to patient and family     0.019   Yes 106 60.4     No 130 44.