53 +/- 1.00 cm(2)) were less accurately sized than defects on either of the condyles (p < 0.01). The areas of PX-478 concentration defects that were <2 cm(2) were overestimated (mean, 0.21 +/- 0.65 cm(2)) compared with other sizes of defects (p < 0.001), and the areas of defects that were >4 cm(2) were underestimated (mean, -0.87 +/- 1.83 cm(2)) compared with other defects (p < 0.001).
Conclusions and Clinical Relevance: Our current treatment algorithms rely heavily on the size of a cartilage
defect, but only 57% of the measurements in this study would have accurately led to the appropriate surgical procedure. There is a need to evaluate and quantify the size of a lesion more appropriately than current standards eFT508 allow and potentially revise existing
treatment algorithms.”
“Background: Physical functioning is without restriction in most pediatric heart transplant survivors, but only limited data are available about neuropsychologic outcomes in these children. in this study we assess neurodevelopmental outcomes in transplant survivors in comparison to population norms.
Methods: Neuropsychologic evaluations were performed 12 to 24 months (mean 16 months) post-transplant in 21 children ranging in age from I to 101 months (median 15 months) at time of transplant. Outcomes included verbal, non-verbal and overall intelligence; visual-motor integration skills; and adaptive functioning.
Results: Transplant recipients had a mean overall IQ of 86.7, verbal IQ of 88.4 and non-verbal IQ of 87.5, all significantly Autophagy Compound Library solubility dmso below the normative population mean of 100 (p < 0.01). Thirty-eight to 43% of subjects had low IQ scores (i.e., <85), significantly more than the normative 16% base rate (p < 0.02). Children with an initial diagnosis of congenital heart disease (CHD) had lower overall IQ (mean 78.6) than those with cardiomyopathy
(mean 91.7). The mean expressive language score was 88.1, significantly below norms (p < 0.01), with 46% having low scores (p = 0.01). Receptive language was normal in the same patients (mean 96.8). Finally, 63% of patients had visual-motor deficits and 48% had fine motor deficits (p < 0.005 compared with norms).
Conclusions: Although many pediatric heart transplant recipients display normal neurodevelopmental functioning, this population is at increased risk for cognitive difficulties, especially in expressive language, visual-motor integration and fine motor skills. Children with CHD may be at especially high risk. Early identification and intervention are essential to promote optimal neuropsychologic outcomes and overall quality of life in pediatric heart transplant recipients. J Heart Lung Transplant 2009;28: 1306-11. Copyright (C) 2009 by the International Society for Heart and Lung Transplantation.