7 ± 11.0 59.7 ± 16.0 0.284 Gender Male 44 22 0.690 Female 24 10 BMI 23.3 ± 4.0 22.1 ± 3.4 0.161 Serum adiponectin (μg/ml) 7.4 ± 5.0 8.9 ± 6.1 0.193 Macroscopic type Elevated 8 3 0.722 Depressed/flat 60 29 Depth of invasion T1 34 12 0.242 T2, T3 and T4 34 20 Histological type differentiated 33 7 0.011 undifferentiated 35 25 Lymphatic invasion positive 49 25 0.519 negative 19 7 Venous invasion positive 37 18 0.863 negative 31 14 Lymphatic metastasis positive
BMS202 manufacturer 33 24 0.013 negative 35 8 Peritoneal dissemination positive 8 9 0.042 negative 60 23 Stage I and II 49 18 0.171 III and IV 19 14 Table 3 Expression of AdipoR2 and clinicopathological characteristics in gastric cancer patients. AdipoR2 positive (n = 72) AdipoR2 negative (n = 28) p value Age (y) 62.1 ± 12.3 60.7 ± 14.2 0.624 Gender Male 52 14 0.035 Female 20 14 BMI 22.9 ± 3.9 23.1 ± 3.8 0.719 Serum adiponectin (μg/ml) 7.9 ± 5.5 8.0 ± 5.1 0.968 Macroscopic type Elevated 10 1 0.139 Depressed/flat 62 27 Depth of invasion T1 33 13 0.957 T2, T3 and T4 39 15 Histological type differentiated 36 4 0.001 undifferentiated 36 24 Lymphatic invasion positive 55 19 0.382
negative 17 9 Venous invasion positive 41 14 0.531 negative 31 14 Lymphatic metastasis ASP2215 purchase positive 42 15 0.666 negative 30 13 Peritoneal dissemination positive 11 6 0.462 negative 61 22 Stage I and II 46 21 0.289 III and IV 26 7 Survival analysis Survival rates according to serum adiponectin
levels, the presence or absence of AdipoR1 expression, and AdipoR2 expression were assessed using the Kaplan-Meier method. There were no significant differences in survival rate between Lck the groups with high and low serum adiponectin levels (p = 0.8342; Figure 5). Figure 5 Survival curves for 100 selleckchem patients with gastric cancer after surgery, according to serum adiponectin level. There was no significant difference between the high serum adiponectin level group (n = 61) and the low serum adiponectin level group (n = 39). Patients with positive AdipoR1 staining had a significantly longer survival rate than those with negative staining (p = 0.01; Figure 6), whereas there were no significant differences in AdipoR2 expression between these 2 groups (p = 0.9871; Figure 7). Figure 6 Survival curves for 100 patients with gastric cancer after surgery, according to AdipoR1 expression. The survival rate of patients with gastric cancer positive for AdipoR1 expression (n = 68) was significantly greater than that of patients negative for AdipoR1 (n = 32). Figure 7 Survival curves for 100 patients with gastric cancer after surgery, according to AdipoR2 expression.