7 ± 11 0 59 7 ± 16 0 0 284 Gender          Male 44 22 0 690    

7 ± 11.0 59.7 ± 16.0 0.284 Gender          Male 44 22 0.690    Female 24 10   BMI 23.3 ± 4.0 22.1 ± 3.4 0.161 Serum adiponectin (μg/ml) 7.4 ± 5.0 8.9 ± 6.1 0.193 Macroscopic type          Elevated 8 3 0.722    Depressed/flat 60 29   Depth of invasion          T1 34 12 0.242    T2, T3 and T4 34 20   Histological type          differentiated 33 7 0.011    undifferentiated 35 25   Lymphatic invasion          positive 49 25 0.519    negative 19 7   Venous invasion          positive 37 18 0.863    negative 31 14   Lymphatic metastasis          positive

BMS202 manufacturer 33 24 0.013    negative 35 8   Peritoneal dissemination          positive 8 9 0.042    negative 60 23   Stage          I and II 49 18 0.171    III and IV 19 14   Table 3 Expression of AdipoR2 and clinicopathological characteristics in gastric cancer patients.   AdipoR2 positive (n = 72) AdipoR2 negative (n = 28) p value Age (y) 62.1 ± 12.3 60.7 ± 14.2 0.624 Gender          Male 52 14 0.035    Female 20 14   BMI 22.9 ± 3.9 23.1 ± 3.8 0.719 Serum adiponectin (μg/ml) 7.9 ± 5.5 8.0 ± 5.1 0.968 Macroscopic type          Elevated 10 1 0.139    Depressed/flat 62 27   Depth of invasion          T1 33 13 0.957    T2, T3 and T4 39 15   Histological type          differentiated 36 4 0.001    undifferentiated 36 24   Lymphatic invasion          positive 55 19 0.382

   negative 17 9   Venous invasion          positive 41 14 0.531    negative 31 14   Lymphatic metastasis     ASP2215 purchase      positive 42 15 0.666    negative 30 13   Peritoneal dissemination          positive 11 6 0.462    negative 61 22   Stage          I and II 46 21 0.289    III and IV 26 7   Survival analysis Survival rates according to serum adiponectin

levels, the presence or absence of AdipoR1 expression, and AdipoR2 expression were assessed using the Kaplan-Meier method. There were no significant differences in survival rate between Lck the groups with high and low serum adiponectin levels (p = 0.8342; Figure 5). Figure 5 Survival curves for 100 selleckchem patients with gastric cancer after surgery, according to serum adiponectin level. There was no significant difference between the high serum adiponectin level group (n = 61) and the low serum adiponectin level group (n = 39). Patients with positive AdipoR1 staining had a significantly longer survival rate than those with negative staining (p = 0.01; Figure 6), whereas there were no significant differences in AdipoR2 expression between these 2 groups (p = 0.9871; Figure 7). Figure 6 Survival curves for 100 patients with gastric cancer after surgery, according to AdipoR1 expression. The survival rate of patients with gastric cancer positive for AdipoR1 expression (n = 68) was significantly greater than that of patients negative for AdipoR1 (n = 32). Figure 7 Survival curves for 100 patients with gastric cancer after surgery, according to AdipoR2 expression.

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