8: other specified congenital malformations of the intestine; ICD-10-CM K38.8: intussusception of the appendix) as well as for possible complications of intussusception, such as bowel obstruction. This data was compared to previously published data from the same hospital (January 1, 1995 to June 30, 2001) that was collected using the similar methodology [11] Patients with primary idiopathic intussusception confirmed by surgery, air or liquid-contrast enema as level 1 according to the Brighton Collaboration Clinical Case Definition, were included in the analysis [15]. To examine the Crizotinib possibility of a temporal association

between receipt of a rotavirus vaccine and intussusception, we obtained vaccination records from the Australian Childhood Immunisation

Register [16]. We compared the date of rotavirus immunisation to the recorded date of intussusception diagnosis, the age of each patient at the time of vaccination and the number and date of doses received. Data were entered and stored in a secure Microsoft Access 2003 database. Incidence rates were calculated using age specific population estimates for Victorian children obtained from the Australian Bureau of Statistics for each year of the study [17]. Ninety-five per cent confidence intervals for incidence rates and click here their ratios were calculated using standard methods based on Poisson distribution. Poisson regression analysis was used to estimate incidence rate ratios that describe the difference in incidence rate for each age group from the beginning to the end of the study period. Statistical analysis was performed using Stata 10.0 (StataCorp, College Station, TX, USA). This study was approved by the Ethics in Human Research Committee at the Royal Children’s Hospital, Melbourne. A total of 258 episodes of IS were identified in 230 children aged 24 months or less over the 8-year study period. Thirty-three patients were excluded from the final analysis. This

included 11 patients whose diagnosis was secondary to underlying pathologies such as; Meckel’s Diverticulum (n = 6), duplication cyst (n = 1), prolapsed Tolmetin stoma (n = 1) and post operative IS (n = 3). In addition, 21 cases of IS were found to be unproven on surgical or radiological investigations, and 1 case lacked sufficient data to make a complete assessment (n = 1). Approximately 9% (n = 28) of episodes were misclassified or coded incorrectly. Sixty-four cases were identified under codes that could be associated with intussusception and miscoded, although a subset analysis of these cases found no miscoded cases of intussusception. Four cases were not born in Victoria but presented to RCH for diagnosis and treatment of intussusception during the study.