Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, Medzhitov R, Fikrig E, Flavell RA: Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med 2002,8(8):878–884.PubMed 8. Darrah PA, Monaco MC, Jain S, Hondalus MK, Golenbock DT, Mosser DM: Innate immune responses to Rhodococcus equi. J Immunol 2004,173(3):1914–1924.PubMed 9. Young DB, Garbe T: Lipoprotein antigens of M. tuberculosis. Res Microbiol 1991, 142:55–65.CrossRefPubMed 10. Peirs P, Lefevre P, Boarbi S, Wang XM, Denis O, Braibant M, Pethe K, Locht C, Huygen K, Content J: GDC-0973 cost Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient

in phosphate uptake this website and demonstrates reduced in vivo virulence. Infect Immun 2005,73(3):1898–1902.CrossRefPubMed 11. Sander P, Rezwan M, Walker B, Rampini SK, Kroppenstedt RM, Ehlers S, Keller C, Keeble JR, Hagemeier M, Colston MJ, et al.: Lipoprotein processing is required for virulence of Mycobacterium tuberculosis. Mol Microbiol 2004,52(6):1543–1552.CrossRefPubMed 12. Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT,

Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, et al.: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 1999,285(5428):732–736.CrossRefPubMed 13. Noss EH, Pai RK, Sellati TJ, Radolf JD, Belisle J, Golenbock DT, Boom WH, Harding CV: Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing NVP-BSK805 research buy by 19-kDa lipoprotein of Mycobacterium tuberculosis. J Immunol 2001,167(2):910–918.PubMed 14. Lopez M, Sly LM, Luu Y, Young D, Cooper H, Reiner NE: The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2. J Immunol 2003,170(5):2409–2416.PubMed PTK6 15. Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, Ernst JD: Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent

mechanisms. J Immunol 2004,172(10):6272–6280.PubMed 16. Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa MT, Engele M, Sieling PA, Barnes PF, Rollinghoff M, Bolcskei PL, Wagner M, et al.: Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 2001,291(5508):1544–1547.CrossRefPubMed 17. Ciaramella A, Cavone A, Santucci MB, Garg SK, Sanarico N, Bocchino M, Galati D, Martino A, Auricchio G, D’Orazio M, et al.: Induction of Apoptosis and Release of Interleukin-1 beta by Cell Wall-Associated 19-kDa Lipoprotein during the Course of Mycobacterial Infection. J Infect Dis 2004,190(6):1167–1176.CrossRefPubMed 18. Post FA, Manca C, Neyrolles O, Ryffel B, Young DB, Kaplan G: The 19 kDa lipoprotein of Mycobacterium tuberculosis inhibits Mycobacterium smegmatis induced cytokine production by human macrophages in vitro. Infect Immun 2001, 69:1433–1439.CrossRefPubMed 19.