Concomitant coronary artery bypass grafting was performed in 6 patients. Transthoracic echocardiography was performed at baseline, at discharge, at 4 to 6 Avapritinib molecular weight months, at 11 to 14 months, and annually thereafter.
Results: Valve implantation was successful in 30 patients. The procedure was converted to conventional aortic valve replacement in 2 patients. Mean bypass time
was 111 +/- 42 minutes, and crossclamp time was 70 +/- 23 minutes. Valve implantation took 21 +/- 7 minutes. The transvalvular gradients at discharge were 10 +/- 3 mm Hg (mean) and 20 +/- 7 mm Hg (peak), and the effective orifice area was 1.9 +/- 0.4 cm(2). At 2-year follow-up, gradients were 7 +/- 3 mm Hg (mean) and 14 +/- 4 mm Hg (peak), and the effective orifice area was 1.9 +/- 0.3 cm(2). There was no intraoperative mortality: Two patients died of causes unrelated to the valve during follow-up. One redo aortic valve replacement was performed at 22 months for prosthetic valve endocarditis.
Conclusions: Sutureless aortic valve replacement is feasible and safe with the Trilogy System. After an initial learning curve, the modular valve design allows a more rapid and simple implantation compared with conventional stented tissue valves. The simplicity may also facilitate
a greater adoption of JAK inhibitor minimally invasive aortic valve replacement by a broader spectrum of surgeons. (J Thorac Cardiovasc Surg 2010;140:878-84)”
“BACKGROUND: As brain temperature is reported to be extensively higher than core body temperature in traumatic brain injury (TBI) patients, posttraumatic hyperthermia is of particular relevance in the injured brain.
OBJECTIVE: To study the influence of prophylactic normothermia on brain temperature and the temperature gradient between
brain and core body in patients with severe TBI using an intravascular cooling system and to assess the relationship between brain temperature and intracranial pressure (ICP) under endovascular temperature control.
METHODS: Prospective case series study conducted in the neurologic intensive care unit of a tertiary care university hospital. Seven patients with severe TBI with a Glasgow Coma Scale score of 8 or less were consecutively Endodeoxyribonuclease enrolled. Prophylactic normothermia, defined as a target temperature of 36.5 degrees C, was maintained using an intravascular cooling system. Simultaneous measurements of brain and urinary bladder temperature and ICP were taken over a 72-hour period.
RESULTS: The mean bladder temperature in normothermic patients was 36.3 +/- 0.4 degrees C, and the mean brain temperature was determined as 36.4 +/- 0.5 degrees C. The mean temperature difference between brain and bladder was 0.1 degrees C. We found a significant direct correlation between brain and bladder temperature (r = 0.95). In 52.4% of all measurements, brain temperature was higher than core body temperature.