Etoposide was loaded into micelles by film casting using various drug/polymer ratios. Drug release was studied by the dialysis method. The structure of copolymers was confirmed by H-1 NMR and FTIR. Central micellar concentration (CMC) measurements showed that the longer hydrophobic chains formed more thermodynamically stable micelles. Among the prepared copolymers, etoposide showed the highest solubility in the mPEG-behenic copolymer. Drug loading efficiency depended on the hydrophobic chain length and drug/polymer

ratio. The highest drug loading efficiency was this website found in mPEG-myristic micelles with 1: 20 drug/polymer ratio. Micelles released 80 % of loaded drug within about 5 h.”
“T lymphocytes recognize lipid antigens as complexes formed by lipids with CD1 antigen-p resenting molecules. These complexes are formed within antigen-presenting cells after lipid internalization and their stability contributes to lipid immunogenicity. Immunogenic lipids are amphiphatic structures that insert the hydrophobic tails within the antigen-binding pockets of CD1 molecules and leave their hydrophilic moieties exposed for interaction with T-cell receptors. Minimal variations in

both parts influence T-cell recognition, which demonstrates a high grade of specificity. Presentation of lipid antigens requires their efficient internalization, traffic to endosomal compartments where CD1 molecules Belinostat order are encountered, extraction from the membrane, and insertion into CD1 lipid-binding pockets. This article

reviews how these events occur and how they are regulated.”
“Dielectric properties of Ba0.7Sr0.3TiO3 (BST) thin films, which were prepared on silicon-based substrates by ion beam sputtering and postdeposition annealing method, were systematically investigated in different electrode configurations of metal-insulator-metal and coplanar interdigital capacitors. It was found that a large dielectric anisotropy exists in the films with better in-plane dielectric properties (higher dielectric permittivity and tunability) than those along the out-of-plane direction. The observed anisotropic dielectric responses are explained qualitatively in terms SCH727965 price of a thermal strain effect that is related to dissimilar film strains along the in-plane and out-of-plane directions. Another reason for the dielectric anisotropy is due to different influences of the interfacial low-dielectric layer between the BST film and the substrate (metal electrode). (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3186019]“
“A simple RP-HPLC method for the quantification of valsartan (VAL), amlodipine (AML) and hydrochlorothiazide (HCT) in human plasma was developed and validated. VAL, AML and HCT were resolved using a Gemini C-18 column and mobile phase gradient starting from 20 % acetonitrile and 80 % 10 mmol L-1 ammonium formate (V/V, pH 3.5 +/- 0.2, by formic acid) to 70 % acetonitrile and 30 % 10 mmol L-1 ammonium formate, over 20 minutes, with a flow rate of 1 mL min(-1).