Methods: Patients referred for primary PCI and TH between July 2004 and April 2011 were identified from the University of Ottawa Heart Institute STEMI database. The primary endpoint was survival to hospital discharge with sufficient neurologic recovery to enable discharge home.
Results: Among 2467 consecutive patients selleck screening library referred for primary PCI, we identified
50 patients treated with TH following OHCA. Forty-nine underwent PCI, of which 47 (96%) received a stent. Median door-to-balloon time was 113 min (IQR 91-151). Patients with good neurologic recovery were younger, mean 51 +/- 9 years versus 64 +/- 12, p < 0.001, and had higher baseline creatinine clearance, 70 +/- 19 mL/min/1.73 m(2) versus 53 +/- 23 mL/min/1.73 m(2), p = 0.007. The primary
endpoint of survival with sufficient neurologic recovery to enable discharge home was reached in 30 patients (60%). Four survivors required levels of assistance that precluded discharge home.
Conclusions: Therapeutic hypothermia in conjunction with primary PCI is associated with a favorable neurologic outcome in the majority of STEMI patients surviving OHCA. Our results suggest that TH is an important adjunctive therapy for STEMI Selleckchem EGFR inhibitor patients suffering OHCA. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Objective: Alterations in joint mechanics selleck products can cause osteoarthritis, which results in degeneration of both cartilage and bone tissue. The objective of this work is to measure changes in the laxity of the mouse knee joint after destabilisation of the medial meniscus (DMM) and to visualise and quantify the resulting three-dimensional changes in the bone and cartilage.
Methods: Skeletally mature C57Bl6 male mice underwent DMM surgery in the right leg. Animals were sacrificed immediately 0 weeks (n = 15), 4 weeks (n = 11) or 8 weeks (n = 12) after surgery. For the 0-week group, the anterior posterior (AP) and varus valgus laxity of the DMM limb were compared to the contralateral limb. For 4 and 8-week groups,
tibiae were scanned with micro-computed tomography (mu ACT) to quantify and visualise bone changes and with confocal scanning laser microscopy (CSLM) to measure changes in cartilage.
Results: Laxity testing measured an increase in AP range of motion, particularly in the anterior direction. The DMM limbs showed a decrease in epiphyseal trabecular bone at 8 weeks and a decrease in cartilage volume, primarily on the posterior medial plateau, compared to the contralateral limb. Significant bone remodelling was observed at the periphery of the joint and in severe cases, osteolysis extended through the growth plate.
Conclusion: Multimodal imaging allowed quantifiable 3D assessment of bone and cartilage and indicated extensive changes in the tissues.