“
“Neodymium-doped silicon-rich silicon oxide thin films SiOx:Nd (1 smaller than = x smaller

than = 2) were deposited by thermal co-evaporation of SiO and SiO2 and annealed at temperatures up to 1200 C. Due to the phase separation process induced by annealing treatments, amorphous silicon nanoparticles (aSi-np) are obtained. For annealing temperatures equal to or above 1000 degrees C, silicon nanocrystals (Si-nc) embedded in a SiO2 matrix are obtained. Photoluminescence (PL) properties of the SiOx:Nd thin films were studied as a function of the silicon excess, the annealing temperature and the Nd content. For annealed samples, Nd-related PL peaks at 920 nm, 1100 nm and 1400 nm are observed. It is shown that, despite the efficient

energy transfer between Si-nc and Nd3+ ions, the highest luminescence this website intensity is obtained for samples containing aSi-np. Moreover, the concentration quenching effect occurs for higher concentration values in samples containing aSi-op, compared to that containing Si-nc. These results show that Si-nc are not necessary to indirectly excite Nd3+ ions and that samples annealed Proteasome purification at temperatures lower than 800 degrees C are of potential interest for applications because of a lower thermal budget compared to that required for samples containing Si-nc. (C) 2014 Elsevier B.V. All rights reserved.”
“Temozolomide is a chemotherapeutic drug that is mainly used in the treatment of primary glioblastoma multiforme and recurrent high-grade glioma. Here, we report an efficient good manufacturing practice compliant method for the synthesis of [3-N-C-11-methyl]temozolomide from 3-N-hydroxymethyl temozolomide that cleaves off formaldehyde in situ and becomes activated towards alkylation with [C-11]methyl iodide. The labelling method was developed for an on-going patient study in which the predictive value of [3-N-C-11-methyl]temozolomide and positron emission

tomography on the outcome of temozolomide treatment is being investigated. The precursor was reacted with [C-11]methyl iodide in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile, heated at stepwise increasing temperature. Purification by semipreparative HPLC with pharmaceutical PI3K inhibitor grade eluent and filtration gave approximately 10mL sterile product solution ready for injection containing 1.55 +/- 0.38GBq (n=5), the specific activity was 88 +/- 25GBq/mu mol and the radiochemical purity was 98.5 +/- 1.9%. C-13-NMR spectroscopy confirmed the labelled position after colabelling with C-11 and C-13.”
“Inefficient muscle long-chain fatty acid (LCFA) combustion is associated with insulin resistance, but molecular links between mitochondrial fat catabolism and insulin action remain controversial.