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“Objective: To provide a patient-centered medical home (PCMH) primer for pharmacists, including basic background information, key terminology, and examples of success stories.

Data sources: PCMH literature and resources obtained through search strategies by authors including but not limited to PubMed and Google Scholar.

Summary: PCMHs are a potential means of achieving cost reduction in health care and providing collaborative and comprehensive care, and they represent a promising option for achieving health care reform. Medication therapy management and collaborative

drug therapy management this website are possible means for pharmacists to fulfill the goals of PCMHs.

Conclusion: Pharmacists must become knowledgeable of standards of PCMH and their abilities to fulfill these standards. Advocacy at local, state, and national levels is needed to achieve recognition of the value of pharmacists in PCMHs.”
“Background: Actinic keratoses (AK) are squamous cell carcinomas in situ and NVP-LDE225 purchase require treatment. Betulin-based oleogel prepared from a standardized triterpene dry extract from birch bark represents a new topical agent with anti-inflammatory and anti-tumor potential.

Patients and Methods: In the prospective, randomized, monocentric phase 2a study 45 patients with <= 10 AK were included and randomly assigned

to one of the three treatment groups. Intervention consisted of topical betulin-based oleogel twice daily versus cryotherapy with liquid nitrogen versus the combination of cryotherapy with topical betulin-based oleogel. Treatment response was assessed clinically after three months. The clinical response was graded into complete

clearing (100 %), therapy responders (>= 75 % clearing of the lesions) and non-responders (< 75 % clearing). Additionally, punch biopsies were obtained from some patients before and at the end of treatment.

Results: Therapy with betulin-based oleogel was well tolerated. Three patients discontinued therapy because of personal reasons. After three months, the 100 % (and > 75 %) clearing rates of the lesions were as follows: 64 % (86 %) with betulin-based oleogel (n = 14), 79 % (93 %) with cryotherapy (n = 14), and 71 % (71 %) with the combined therapy (n = 14). Histological VX-809 mw analysis of biopsies taken before and after treatment (n = 8) showed a reduced degree of dysplasia in the epidermis in all study arms.

Conclusions: Betulin-based oleogel seems to be an effective novel approach in the topical treatment of actinic keratoses. However, the clinical and histological findings of the present pilot study have to be verified against placebo with larger case numbers.”
“OBJECTIVE: To evaluate glycemic control and pregnancy outcomes among pregnant women with severe insulin resistance treated with 500 units/mL concentrated insulin.