The level of significance was considered as P < 0.05. Multivariate logistic regression analysis was used to determine predictor variables that predict the postoperative complications, hospital stay and mortality. Ethical consideration Ethical approval to conduct the study was obtained from the CUHAS-Bugando/BMC joint institutional ethic review committee before the commencement of the study. Patients were required to sign a written informed consent for the study and for HIV testing. Results Socio-demographic data During the study period, a total of 2643 patients were admitted

to our centre and underwent laparotomy for various abdominal conditions. Of these 527 patients underwent laparotomy for bowel obstruction. Out of 527 patients, the underlying cause of SYN-117 obstruction was

intestinal tuberculosis confirmed by histopathology in 129 patients. Of these, 11 patients were excluded from mTOR activity the study due failure to meet the inclusion criteria. Thus, 118 patients representing 22.4% of cases (i.e. 118 out of 527 patients) were enrolled into the study. Seventy-six (64.4%) were males and 42 (35.6%) females, with a male to female ratio of 1.8: 1. The age of patients at presentation ranged from 11 to 67 years with a median age of 26 years. The peak age incidence was in the age group of 21-30 years accounting for 50.0% of cases (Figure 1). Eighty-eight (74.6%) patients https://www.selleckchem.com/products/17-AAG(Geldanamycin).html were aged 40 years and below. Most of patients, 91 (77.1%) had either primary or no formal education and more than 75% of them were unemployed. The majority of patients, 86 (72.9%) came from the rural areas located a considerable distance from the study area and more than 80% of them had no identifiable health insurance. Figure 1 Distribution of patients according to age group. Clinical presentation among patients with tuberculous bowel obstruction The duration of symptoms prior to admission varied between 4 days to 12 months with a median of 8 months. The majority of our patients, 68 (57.6%) had symptoms of more than 6 months duration at the time of presentation. Out of 118 patients, 87 (73.7%) were considered to have primary intestinal tuberculosis

and the remaining 31 (26.3%) had secondary intestinal tuberculosis (i.e. associated with pulmonary tuberculosis) with 3-mercaptopyruvate sulfurtransferase remarkable chest x-rays, past history of pulmonary tuberculosis was positive in only 28 patients (23.7%). Out of these, eight patients were on treatment with anti-tuberculous drugs while fourteen had already taken a complete course of anti-tubercular drugs. The remaining six patients were defaulters. Sixty two (51.5%) patients presented with acute intestinal obstruction, thirty-four (28.8%) with sub-acute intestinal obstruction, sixteen (13.6%) with signs of peritonism and six (5.1%) with abdominal mass. Abdominal pain was the most common symptom and occurred in all cases (Table 2). In this study, twelve (10.