This benchmark study is the WHO study Psychological MLN8237 molecular weight disorders in Primary Care, and was conducted in 18 countries in the eighties.7 Although only a small proportion of mental disorders were covered, the total point prevalence of threshold ICD-10 diagnoses across centers was 24%, with some variation between countries (from 20% in Shanghai to 50% in Santiago de Chile). Major depressive disorders (10%) and generalized anxiety disorders (GADs, 8%) were Inhibitors,research,lifescience,medical the most frequent diagnoses, followed by neurasthenia (5%), alcohol dependence (3%), and somatization disorder (3%) (Table I), This study focused on threshold cross-sectional diagnoses and excluded partially remitted or subthreshold

disorders; the estimates can thus be regarded as conservative. In terms of recognition and treatment, Inhibitors,research,lifescience,medical the study revealed that GPs recognized only 49% of the mental disorders ascertained by the study instrument. Moreover, only about half of all cases recognized received

some specific intervention, and the majority of these treatments were not considered to be state of the art first-line treatments. Another puzzling result was that, in addition to the 25% rate of threshold disorders, the treating Inhibitors,research,lifescience,medical physicians also labeled an additional 11% of patients as having a mental disorder that was not ascertained by the study instrument. It remains unclear whether a proportion of these patients were incorrectly diagnosed, or whether these findings reflect partially remitted mental disorders or an episode that did not yet meet current research criteria, or indeed whether the patients or diagnoses were not completely covered by Inhibitors,research,lifescience,medical the research study. Table I Prevalence of current International Statistical Classification of Diseases, 10th Revision (ICD-10)9 disorders7 according to the Composite Inhibitors,research,lifescience,medical International Diagnostic Interview (CIDI). The study also highlighted a tremendous

variation between centers and between diagnoses in terms of prevalence, recognition, and treatment. This variation may indicate considerable differences in provider models of primary care around the world, cultural distinctions, and the fact that well defined disorders (like depression) are better recognized, diagnosed, Non-specific serine/threonine protein kinase and treated than rarer and ill-defined conditions.13 Depressive disorders Studies in the 1980s and early 1990s conducted in primary care in various countries with fairly convergent methods and designs14 confirmed that depression is indeed a quite frequent problem in primary care. The point prevalence for depressive disorders has been estimated with some variation to be about 10% of all primary care attendees.7,15-19 There is also fairly consistent agreement that, among patients with clinically significant depression, over 50% were not recognized by the treating primary care physician.