We show that the model based on the mRNA diffusion hypothesis is

We show that the model based on the mRNA diffusion hypothesis is consistent with the known observational data, supporting the recent experimental findings of the gradient of bicoid mRNA in Drosophila [Spirov et al. (2009). buy ARN-509 Development 136, 605-614]. (C) 2010 Elsevier Ltd. All rights reserved.”
“BACKGROUND: O-6-methylguanine methyltransferase (MGMT) promoter methylation in adult glioblastomas (glioblastoma multiforme) is considered a promising molecular alteration, predictive of better response to temozolomide therapy

and longer overall survival.

OBJECTIVE: To look at the frequency of MGMT methylation in glial tumors of all grades and types, and correlate this alteration with loss of heterozygosity 1p/19q, TP53 gene mutations, epidermal growth factor receptor (EGFR) amplification, and isocitrate dehydrogenase 1 (IDH1) mutations.

METHODS: One hundred two gliomas of various grades and subtypes were assessed by methylation-specific polymerase chain reaction for MGMT promoter methylation status. The results were correlated with 1p/19q status, EGFR amplification, TP53, and IDH1 mutations.

RESULTS: There was an inverse correlation of MGMT promoter methylation frequency with tumor grade, observed in 79.4%, 70.8%, and 56.8% of grade II, grade III, and grade IV gliomas, respectively.

The difference was statistically significant in grade II vs IV tumors (P = .036). The majority of cases with 1p/19q loss of heterozygosity Erythromycin also showed MGMT methylation, although the association was not significant. check details There was no significant correlation of MGMT status with IDH1 mutation. In astrocytic tumors, there was no correlation of MGMT methylation with

TP53 mutation or EGFR amplification.

CONCLUSION: MGMT promoter methylation was observed in a considerable proportion of all grades and subtypes of gliomas, with no significant correlation with other known genetic alterations. On extensive literature review, in both low-and high-grade gliomas, wide variability of data on the frequency of MGMT methylation and its association with other molecular alterations from various centers was noted, mostly owing to technical causes. This raises questions regarding the capacity of this test for use as an objective and reproducible marker for customized treatment in individual cases.”
“BACKGROUND: Although coiling of intracranial aneurysms is thought to rely on obstruction of blood flow into the aneurysm and induction of intra-aneurysmal thrombosis, little data exist regarding the effect of coil deployment on hemodynamics.

OBJECTIVE: To evaluate the effects of simulated coiling of a model aneurysm on flow and wall shear stress in the dome and neck regions using computational fluid dynamic analysis.

METHODS: A spherical sidewall aneurysm on a curved parent vessel underwent simulated embolization with 1 or more computer-designed helical coils.

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