We wished to examine the effects GP IIb-IIIa inhibitors alone or

We wished to examine the effects GP IIb-IIIa inhibitors alone or in combination with thrombolytic agents. Search methods We searched the Cochrane Stroke Group trials register (last searched 10 June 2013), MEDLINE (1966 to June 2013), EMBASE (1980 to June 2013), the Cochrane Central Register of Controlled

Trials (CENTRAL) (The Cochrane Library Issue 5, 2013), and major ongoing clinical trials registers (June 2013). We also searched reference lists and contacted trial authors and pharmaceutical companies. Selection criteria We aimed to analyse unconfounded randomised controlled trials (RCTs) of GP IIb-IIIa inhibitors in the treatment of people with acute ischaemic stroke. Only individuals who started treatment Epigenetics inhibitor within six hours of stroke onset were included. Data collection and analysis We independently selected trials for inclusion, assessed trial quality

and extracted the data. Main results We included four trials involving 1365 participants. Three trials compared the intravenous GP IIb-IIIa inhibitor Abciximab with intravenous placebo (1215 participants) and one trial compared the intravenous GP IIb-IIIa inhibitor Tirofiban with intravenous aspirin (150 participants). Treatment with either of these GP IIb-IIIa inhibitors did not significantly reduce long-term death or dependency (odds ratio (OR) 0.97, 95% confidence interval (CI) 0.77 to 1.22, for MS-275 mw the comparison between Abciximab and placebo; OR 1.00, 95% CI 0.52 to 1.92, for the comparison between Tirofiban and aspirin) and had no effect

on deaths from all causes (OR 1.08, 95% CI 0.77 to 1.53, for the comparison between Abciximab and placebo; OR 1.00, 95% CI 0.35 to FK228 chemical structure 2.82, for the comparison between Tirofiban and aspirin). Abciximab was associated with a significant increase in symptomatic intracranial haemorrhage (OR 4.6, 95% CI 2.01 to 10.54) and with a non-significant increase in major extracranial haemorrhage (OR 1.81, 95% CI 0.96 to 3.41), whereas the only small trial comparing Tirofiban with aspirin showed no increased risk of bleeding complications with Tirofiban (OR 0.32, 95% CI 0.03 to 3.19, for symptomatic intracranial haemorrhage; OR 3.04, 95% CI 0.12 to 75.83, for major extracranial haemorrhages). There was no significant inconsistency across the studies. Authors’ conclusions The available trial evidence showed that, for individuals with acute ischaemic stroke, GP IIb-IIIa inhibitors are associated with a significant risk of intracranial haemorrhage with no evidence of any reduction in death or disability in survivors. These data do not support their routine use in clinical practice. The conclusion is driven by trials of Abciximab, which contributed 89% of the total number of study participants considered.”
“Myxobacteria are Gram-negative soil-dwelling bacteria belonging to the phylum Proteobacteria.

101 vs 0 003, P=0 02 vs 0 13) However, PNa+ was better than DP

101 vs. 0.003, P=0.02 vs. 0.13). However, PNa+ was better than DPNa+ in predicting IDWG (R-2=0.105 vs. 0.019, P=0.04 vs. 0.68) and pre-dialysis systolic blood pressure (R-2=0.103 vs. 0.007, P=0.02 vs. 0.82). We also found that the intradialytic blood pressure fall was greater in frequent nocturnal hemodialysis patients than in short hours daily patients, when exposed to a dialysate to plasma sodium gradient. These results provide a basis for design of prospective trials in quotidian dialysis modalities,

to determine the effect of sodium balance on cardiovascular outcome.”
“Objective. To study the longitudinal rate of (and sensitivity to) change of knee cartilage thickness across defined stages of radiographic osteoarthritis (OA), specifically healthy Epigenetic inhibitor mouse knees and knees with end-stage radiographic OA.\n\nMethods. Smad inhibitor One knee of 831 Osteoarthritis Initiative participants was examined: 112 healthy knees, without radiographic OA or risk factors for knee OA, and 719 radiographic OA knees (310 calculated Kellgren/Lawrence [K/L] grade 2, 300 calculated K/L grade 3, and 109 calculated K/L grade 4). Subregional change in thickness was assessed after segmentation of weight-bearing femorotibial cartilage at baseline and 1 year from coronal magnetic resonance imaging (MRI). Regional

and ordered values (OVs) of change were compared by baseline radiographic OA status.\n\nResults. Healthy knees displayed small changes in plates and subregions (+/- 0.7%; standardized response mean [SRM] +/- 0.15), with OVs being symmetrically distributed close to zero. In calculated SN-38 manufacturer K/L grade 2 knees, changes in cartilage thickness were small (<1%; minimal SRM -0.22) and not significantly different from healthy knees. Knees with calculated K/L grade 3 showed substantial loss of cartilage thickness (up to -2.5%;

minimal SRM -0.35), with OV1 changes being significantly (P < 0.05) greater than those in healthy knees. Calculated K/L grade 4 knees displayed the largest rate of loss across radiographic OA grades (up to -3.9%; minimal SRM -0.51), with OV1 changes also significantly (P < 0.05) greater than in healthy knees. Conclusion. MRI-based cartilage thickness showed high rates of loss in knees with moderate and end-stage radiographic OA, and small rates (indistinguishable from healthy knees) in mild radiographic OA. From the perspective of sensitivity to change, end-stage radiographic OA knees need not be excluded from longitudinal studies using MRI cartilage morphology as an end point.”
“In function approximation problems, one of the most common ways to evaluate a learning algorithm consists in partitioning the original data set (input/output data) into two sets: learning, used for building models, and test, applied for genuine out-of-sample evaluation.

Solubility measurements at various temperatures showed that the t

Solubility measurements at various temperatures showed that the two polymorphs were mutually monotropic and that Form I was the relatively thermodynamically stable crystal form. 0 2011 Elsevier Ltd. All rights reserved.”
“Background: In selected patients undergoing mastectomy and immediate reconstruction, a de-epithelialized skin flap (dermal HM781-36B ic50 sling) may be used to complete the submuscular pocket. This study examined the safety and efficacy of an autologous dermal sling in providing inferolateral support to the implant or tissue expander during immediate breast reconstruction.\n\nMethods: Patients were identified from an electronic

prospective database. Records of all patients were reviewed for details of management, complications and follow-up. Patient satisfaction and quality of life in the postoperative period were determined using the BREAST-Q (R) questionnaire.\n\nResults: Between October 2008 and August 2010, 21 patients underwent 28 dermal sling-assisted breast reconstruction procedures. Their median age was 48 (range 30-70) years. Median hospital stay was 5 (range 3-7) days. Drains were removed at a median of 5 (range 3-7) days after surgery. During the operation a median volume of 150 ml was added to

the tissue expander. The most common postoperative complication was superficial T-junction breakdown in five patients, followed by seroma and infection each in three patients, but no implant required removal. BREAST-Q (R) responses indicated a high level of satisfaction overall with the reconstructed breast.\n\nConclusion: Dermal sling-assisted immediate Selleck CCI-779 breast reconstruction has a low serious complication rate, provides stable soft tissue cover for the tissue expander and is associated with a high level of patient satisfaction. A larger pocket can be created, permitting more fluid to be added to the expander.”
“PURPOSE. Recent studies on diabetic retinopathy (DR) screening in fundus photographs suggest that disagreements between algorithms

and clinicians are now comparable to disagreements among clinicians. The purpose of this study is to (1) determine whether this observation also holds for automated DR severity assessment algorithms, and (2) show the interest of such algorithms in clinical practice.\n\nMETHODS. A dataset of 85 consecutive DR VS-6063 mw examinations (168 eyes, 1176 multimodal eye fundus photographs) was collected at Brest University Hospital (Brest, France). Two clinicians with different experience levels determined DR severity in each eye, according to the International Clinical Diabetic Retinopathy Disease Severity (ICDRS) scale. Based on Cohen’s kappa (kappa) measurements, the performance of clinicians at assessing DR severity was compared to the performance of state-of-the-art content-based image retrieval (CBIR) algorithms from our group.\n\nRESULTS. At assessing DR severity in each patient, intraobserver agreement was kappa = 0.769 for the most experienced clinician.

Calcium hydroxylapatite allows simple and effective alleviation o

Calcium hydroxylapatite allows simple and effective alleviation of aspiration following near-total laryngectomy but requires repeated injection to maintain efficacy. Injection of calcium hydroxylapatite can be an effective alternative to completion laryngectomy in patients who aspirate

following near-total laryngectomy.”
“Recent research on the bioavailability of flavan-3-ols after ingestion of green tea by humans is reviewed. Glucuronide, sulfate, and methyl metabolites of (epi)catechin and (epi)gallocatechin glucuronide reach peak nanomolar per liter plasma concentrations 1.6-2.3 h after intake, indicating absorption in the small intestine. The concentrations then decline, and only trace amounts remain 8 h after ingestion. Urinary excretion of metabolites over a 24-h period after green tea consumption corresponded to 28.5% of the ingested see more (epi)

catechin and 11.4% of (epi)gallocatechin, suggesting higher absorption than that of most other flavonoids. The fate of (-)-epicatechin-3-O-gallate, the main flavan-3-ol in green tea, is unclear because it appears unmetabolized in low concentrations in plasma but is not excreted in urine. Possible enterohepatic recirculation of flavan-3-ols is discussed along with the impact of dose and other food components on flavan-3-ol bioavailability. Approximately two-thirds of the ingested flavan-3-ols pass from the small to selleck the large intestine where the action of the microbiota results in their conversion to C-6-C-5 phenylvalerolactones and phenylvaleric acids, which undergo side-chain shortening to produce C-6-C-1 phenolic and aromatic acids that enter the bloodstream and are excreted in urine in amounts equivalent

to 36% of flavan-3-ol intake. Some of these colon-derived catabolites may have a role in vivo in the potential protective effects of tea consumption. Although black tea, which contains theaflavins and thearubigins, is widely consumed in the Western world, there is surprisingly little research on the absorption and metabolism of these compounds after ingestion and their potential impact on health.”
“Research in mammalian hair cell regeneration is hampered by a lack of in vivo model of adult mouse inner ear injury. In the present study we investigated the effects of a combination PI3K inhibitor of a single dose of aminoglycoside followed by a loop diuretic in adult mice. The auditory brainstem response threshold shift, extent and defining characteristics of the cochlear lesion were assessed and verified at different time points post-treatment. Our data indicated that this drug combination caused the rapid and extensive death of outer hair cells (OHCs). OHC death presented throughout the cochlea that commenced in the basal turn by 24 h and progressed apically. In contrast, inner hair cell (IHC) loss was delayed and mild.

In contrast, ADX61623 did not block estrogen production This dem

In contrast, ADX61623 did not block estrogen production. This demonstrates for the first time, biased antagonism at the FSHR To determine if ADX61623 blocked FSH induction of follicle Stem Cell Compound Library cell assay development in vivo, a bioassay to measure follicular development and oocyte production in immature female rats was validated. ADX61623 was not completely effective in blocking FSH induced follicular development in vivo at doses up to 100 mg/kg as oocyte production and ovarian weight gain were only moderately reduced. These data illustrate that FSHR couples to multiple signaling pathways in vivo. Suppression of one pool of FSHR uncouples Gas and cAMP production,

and decreases progesterone production. Occupancy of another pool of FSHR sensitizes granulosa cells to FSH induced estradiol production. Therefore. ADX61623 is a useful tool to investigate further the mechanism of the FSHR signaling dichotomy. This may lead to a greater understanding

of the signaling infrastructure which enables estrogen biosynthesis and may prove useful in treating estrogen dependent disease. (C) 2010 Elsevier Ireland Ltd. All rights reserved.”
“Background: The aim of the present study was to evaluate the prevalence and severity of lower limb lymphedema after pelvic lymphadenectomy and radiotherapy to the pelvic lymph nodes in Cl-amidine ic50 patients with prostate cancer.\n\nMethods: Twenty-six patients underwent combined treatment for high-risk node-positive prostate cancer at Skane University Hospital between April 2008 and March 2011. The treatment consisted of extended pelvic lymphadenectomy followed by androgen deprivation therapy and radiotherapy.

The pelvic lymphnodes, prostate and seminal vesicles were treated with external beam radiotherapy (EBRT) to an absorbed dose of 50 Gy followed by a brachytherapy (BT) boost of 2×10 Gy to the prostate only. Twenty-two patients accepted an invitation to a clinical examination with focus on lower limb swelling. The median time between the end of radiotherapy and examination was 2.2 years (range 1.2-4.1).\n\nResults: Six patients (27%) experienced grade 1 lymphedema and two patients (9%) grade 2 while none had grade 3 or 4 according to the CTC Common Toxicity Criteria scale 4.0. Three R406 concentration patients required treatment with compression stockings.\n\nConclusion: Brachytherapy and pelvic EBRT have a low incidence of lymphedema (at median 2.2 y after treatment) in patients with high-risk node-positive prostate cancer that have undergone pelvic lymph node dissection.”
“Nitric oxide (NO) plays a central role in the formation of tropospheric ozone, hydroxyl radicals, as well as nitrous and nitric acids. There are, however, large uncertainties around estimates of global NO emissions due to the paucity of data. In particular, there is little information on the rate of NO emission and its sensitivity to processes such as land use changes in dry environments.

(C) 2014 AACR “
“Additional chromosomal abnormalities in acu

(C) 2014 AACR.”
“Additional chromosomal abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as t(8;21), inv(16), and t(15;17) are associated

with higher rates of complete remission and event-free survival. Translocation Dibutyryl-cAMP (15;17) characterizes acute promyelocytic leukemia (APL) (French-American-British class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately 23%-29% of patients with newly diagnosed APL. The prognostic implications of t(8;21) and other secondary cytogenetic aberrations in APL are reviewed here. We present a 47-year-old woman diagnosed with APL whose initial cytogenetic analysis included both t(8;21) and t(15;17). The initial induction chemotherapy included 3 days of idarubicin (12 mg/m(2)/day) and daily all-trans retinoic acid (ATRA; 45 mg/m(2)/day). At the sixth week of treatment, a control bone marrow biopsy was found to be normocellular, Crenigacestat t(15;17) bcr3 and t(8;21) were negative, and t(15;17) bcr1 fusion transcripts were reduced from 5007 (1.78525699%) copies per 1 mu g RNA to 40 (0.00062020%) with real-time quantitative polymerase chain reaction. Consolidation with 4 days of idarubicin (5 mg/m(2)/day), ATRA (45 mg/m(2)/day

for 15 days), and cytarabine (1 g/m(2)/day for 4 days) was then started. However, the patient became pancytopenic and had neutropenic fever after consolidation treatment. Unfortunately, she died 3 months after the time of APL diagnosis, due to acute respiratory distress syndrome-like respiratory problems and multiorgan dysfunction requiring respiratory support

and hemodialysis.”
“Obstructive sleep apnea/hypopnea syndrome (OSAHS) is common in children and it is a disease characterized by recurrent partial or complete upper airway obstruction during sleep, resulting in hypoxemia and/or hypercarbia. Untreated OSAHS can result in serious complications, and has been shown to have a negative effect on health-related quality of life, and imposes a substantial health care burden.”
“Objective: The aim of this prospective study was to evaluate the feasibility and safety of adjuvant S-1 plus docetaxel in patients with stage III gastric learn more cancer. Methods: We enrolled 53 patients with pathological stage III gastric cancer who underwent D2 gastrectomy. They received oral S-1 (80 mg/m(2)/day) administration for 2 consecutive weeks and intravenous docetaxel (40 mg/m(2)) on day 1, repeated every 3 weeks (1 cycle). The treatment was started within 45 days after surgery and repeated for 4 cycles, followed by S-1 monotherapy (4 weeks on, 2 weeks off) until 1 year after surgery. The feasibility of the 4 cycles of chemotherapy, followed by S-1 administration, was evaluated. Results: A total of 42 patients (79.2%, 95% CI 65.9-82.

However, it also led to sharp strength degradation at high temper

However, it also led to sharp strength degradation at high temperature because the metallic phase was easier to be oxidized and get soft at high temperature in air. The effects

of metallic phase on strengthening and toughening were discussed. The improved fracture toughness of composite with metallic phase was attributed to the lower residual tensile stress in the matrix and the interaction of more effective energy consuming mechanisms, such as crack bridged by particle, crack deflection and intragranular grain failure. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.”
“We studied the association between occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and electrical shocks and acute myeloid leukemia (AML) in LDN-193189 datasheet the Nordic Occupational Cancer cohort (NOCCA). We included 5,409 adult AML cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden and 27,045 controls matched by age, sex, and country.

Lifetime occupational ELF-MF exposure and risk of electrical shocks were assigned to jobs reported in the censuses using job-exposure matrices. We estimated hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) using conditional logistic regression adjusted for concurrent occupational exposures relevant for AML risk (e.g., benzene, ionizing this website radiation). We conducted sensitivity analyses with different assumptions to assess the robustness of our results. Approximately 40 % of the subjects were ever occupationally exposed to low levels and 7 % to high levels of ELF-MF, whereas 18 % were ever at low risk and 15 % at high risk of electrical shocks. We did not observe an association between occupational exposure to neither ELF-MF nor electrical shocks and AML. The HR was 0.88 (95 % CI 0.77-1.01) for subjects with high levels of ELF-MF buy NSC23766 exposure and 0.94 (95 % CI 0.85-1.05) for subjects

with high risk of electrical shocks as compared to those with background-level exposure. Results remained materially unchanged in sensitivity analyses with different assumptions. Our results do not support an association between occupational ELF-MF or electric shock exposure and AML.”
“This study evaluated the ‘constancy’ of head turning as recorded two-dimensionally by accelerometers. Fourteen healthy participants turned the head with his/her natural and comfortable speed. Maximum inclination angles (MIA) during head turning were measured in four (anterior, posterior, right, and left) directions of clockwise (CW) and counter-clockwise (CCW) conditions. Three indices were used for the evaluation: (1) standard deviations of MIA as an index of ‘spatial constancy,’ (2) anterior/posterior and right/left ratios from intervals among four MIA as indices of ‘temporal constancy,’ and (3) first derivatives from head turning trajectories as an index of ‘angular velocity.’ The spatial index varied from 0.15A degrees to 9.

This review outlines the basic concept of STAT signaling, the rel

This review outlines the basic concept of STAT signaling, the relevance of individual members of the STAT family for cellular signaling and human disease, and generally applicable approaches taken to the identification of small-molecule inhibitors of STATs.”
“Disorders of iron metabolism are a significant check details problem primarily in young and old populations. In this study, We compared 1-year-old C57BL6/J mice on iron

deficient, iron overload, or iron sufficient diets with two similarly aged genetic models of disturbed iron homeostasis, the sla (sex-linked anemia), and the ceruloplasmin knockout mice (Cp (-/-)) on iron sufficient diet. We found tissue specific changes in sla and nutritional iron deficiency including decreased liver Hamp1 expression and increased protein expression of the enterocyte basolateral iron www.selleckchem.com/products/ly2606368.html transport components, hephaestin and ferroportin. In contrast, the Cp (-/-) mice did not show significantly increased Hamp1 expression despite increased liver iron suggesting that regulation is independent of liver iron levels. Together, these results suggest that older mice have a distinct response to alterations in iron metabolism and that age must be considered in future

studies of iron metabolism.”
“Thousands of people were infected with Vibrio cholerae during the outbreak in Iraq in 2007-2009. Vibrio cholerae was shown to be variable in its content of virulence determinants and in its antibiotic sensitivity. This study was designed to isolate and characterize clinical and environmental V. cholerae isolates and to determine antibiotic sensitivity, enzyme and toxin production, and the presence of virulence genes. Eighty clinical and five environmental bacterial isolates were collected and diagnosed by subjecting them to microscopic, biochemical, serological, and molecular analysis. The results revealed that 55% of clinical isolates belonged to the Inaba serotype, 32.5% to the Ogawa serotypes, and 12.5% to the Non-O1

serotype. All environmental V. cholerae isolates belonged to the Non-O1 serotype. All environmental isolates were sensitive to all https://www.selleckchem.com/products/gilteritinib-asp2215.html examined antimicrobial agents, while all clinical isolates showed a high sensitivity (100%) to ampicillin, gentamicin, cephalothin, tetracycline, erythromycin, and ciprofloxacin, and a high resistance (97.5%) to co-trimoxazole, nalidixic acid, and chloramphenicol. It was found that all V cholerae (O1) isolates were resistant to the Vibrio static O129 and all Non-O1 V. cholerae isolates were sensitive to the Vibrio static O129. All clinical and environmental isolates produced hemolysin (100%) and lecithinase (100%), while they showed various production rates of protease (90% of clinical and 60% of environmental) and lipase (50% of clinical and 20% of environmental). The ompW gene was amplified in all the clinical and environmental V.

After intravenous administration of gadolinium the mass showed pr

After intravenous administration of gadolinium the mass showed progressively increasing homogeneous enhancement. The lesion was excised without complication and there

was no evidence of recurrence at the 10-month follow-up. Copyright (C) 2009 ISUOG. Published by John Wiley & Sons, Ltd.”
“Cell mechanics play a key role in several fundamental biological processes, such as migration, proliferation, differentiation and tissue morphogenesis. In addition, many diseased conditions of the cell are correlated with altered cell selleck chemicals mechanics, as in the case of cancer progression. For this there is much interest in methods that can map mechanical properties with a sub-cell resolution. Here, we demonstrate an inverted pulsed opto-acoustic microscope (iPOM) that operates in the 10 to 100 GHz range. These frequencies allow mapping quantitatively cell structures CH5424802 price as thin as 10 nm and resolving the fibrillar details of cells. Using this non-invasive all-optical system, we produce high-resolution images

based on mechanical properties as the contrast mechanisms, and we can observe the stiffness and adhesion of single migrating stem cells. The technique should allow transferring the diagnostic and imaging abilities of ultrasonic imaging to the single-cell scale, thus opening new avenues for cell biology and biomaterial sciences.”
“Background: The consistent association between obesity and colorectal cancer is thought to be explained by metabolic disturbances common, but not exclusive, to the obese.\n\nMethods: We assessed the relation between metachronous neoplasia and the components of metabolic syndrome (MetS) as defined by the National Cholesterol ACY-1215 price Education Program’s Adult Treatment Panel III in 2,392 participants of two previously conducted chemoprevention trials. Waist circumference, fasting plasma glucose, trigylcerides, high-density lipoprotein, and systolic and diastolic blood pressure were measured at baseline.\n\nResults:

MetS classification was associated with increased odds of metachronous neoplasia among women [odds ratio (OR), 1.37; 95% confidence interval (95% CI), 1.01-1.85] but not among men (OR, 0.99; 95% CI, 0.81-1.21). High waist circumference in men (OR, 1.41; 95% CI, 1.15-1.72) and women (OR, 1.41; 95% CI, 1.05-1.90) and elevated fasting glucose in women (OR, 1.46; 95% CI, 1.09-1.96), as defined by Adult Treatment Panel III cutpoints, were associated with increased odds, whereas none of the other criteria were independently associated with metachronous neoplasia. When each trait was evaluated using quartiles, elevated glucose among women and large waist circumference among men were significantly associated with metachronous lesions.

Methods: A retrospective analysis was performed on 26 patient

\n\nMethods: A retrospective analysis was performed on 26 patients treated for ABCs: 16 by curettage and 10 by en bloc excision. Each lesion was classified according to Enneking and patients were followed up for a mean time of 9.2 years. On follow-up, radiological examination and functional assessment (range of motion, muscle strength) were performed. Recurrence was defined as the presence of an osteolytic lesion, especially one with a tendency to grow.\n\nResults: On follow-up, the following symptoms were more prevalent in the en bloc excision group compared to the curettage group: pain (en bloc 20% versus curettage

6.25%), limb length differences (en bloc 20% versus curettage 12.5%), reduced range of motion (en bloc 20% versus curettage 6.25%) and muscle strength impairment (en bloc 50% versus curettage 31.2%); however, the differences LGX818 cost were not statistically significant (P >0.05). In the curettage group, two cases of postoperative complications and two cases of recurrence were seen, while in the en bloc excision group one case of complications was noted.\n\nConclusions: Curettage is a standard procedure in ABC management. AZD0530 clinical trial En bloc excision is another option, albeit more

technically demanding, that may be considered in recurrent lesions with extensive bone destruction or for cysts in an expendable location.”
“Introduction The Scottish surgeon Robert Liston was an accomplished anatomist of the nineteenth century. The study of anatomy during this day was often overshadowed by the so-called resurrectionists. Conclusions: The present historic paper reviews the life and contributions of Robert Liston and discusses his fascination with childhood hydrocephalus.”
“Objective. Stattic manufacturer To objectively assess the voice outcomes of patients with unilateral vocal fold paralysis treated with medialization thyroplasty and arytenoid adduction suture.\n\nStudy Design. Case series of patients who underwent medialization thyroplasty and arytenoid adduction suture. Preoperative and postoperative voice testing was performed and the data were compared by statistical analysis.\n\nSetting. Tertiary referral teaching hospital in Sydney, Australia.\n\nSubjects.

All patients had a unilateral vocal fold paralysis, with a large posterior glottic gap and vocal symptoms affecting their quality of life.\n\nMethods. Thirteen patients with a diagnosis of a unilateral vocal fold paralysis with a large posterior glottic gap, vocal symptoms, and total denervation of the vocal fold underwent medialization thyroplasty and arytenoid adduction suture. The surgery was performed in a novel method under a general anesthetic using a laryngeal mask and with direct intraoperative endoscopic feedback. Preoperative and postoperative measures of voice performance were compared, including acoustic analysis (fundamental frequency, speech intensity against quiet and loud background noise, speech rate) and aerodynamic assessment (airflow, maximum phonation time).