The characterization techniques confirmed inclusion complex formation between berberine chloride and HP beta CD and demonstrated the feasibility of developing an oral solution dosage form of the drug.”
“The effect of heat flux levels

on burning behavior and heat transmission properties of hybrid fabrics and composites has been investigated using cone calorimeter and heat transmission Selleck Barasertib techniques. The hybrid fabric structures woven out of E-glass (warp) and polyether ether ketone (PEEK) (weft) and E-glass (warp) and polyester (weft) have been studied at high heat flux levels keeping in view the flame retardant requirements of structural composites. The performance of the glass-PEEK fabric even at high heat flux levels of 75 kW/m(2) was comparable with the performance of glass-polyester fabric evaluated at 50 kW/m(2). The results further demonstrate that glass-PEEK hybrid fabrics exhibit low peak heat release rate, low heat release rate, low heat of combustion, suggesting an excellent combination of materials and fall under the low-risk category and are comparable with the performance of carbon fiber-epoxy-based systems. (C) 2011 Wiley Periodicals,

Inc. J Appl Polym Sci 122: 2295-2301, 2011″
“Satellite cells are a population of adult muscle stem cells that play a key role in mediating muscle regeneration. Activation of these quiescent stem cells in response to muscle injury Dinaciclib order involves modulating expression of multiple developmentally regulated genes, including mediators of the muscle-specific transcription program: Pax7, Myf5, MyoD and myogenin. Here we present evidence suggesting an essential role for the antagonistic Polycomb group and Trithorax group proteins in the epigenetic marking of muscle-specific genes to ensure proper temporal and spatial expression during muscle regeneration. The importance of Polycomb group and Trithorax group proteins in establishing

chromatin structure at muscle-specific genes suggests that therapeutic modulation of their activity in satellite cells could represent a viable approach for repairing damaged muscle in muscular dystrophy.”
“A target product profile (TPP) describes how a product will be utilized by the end user. A systematically developed TPP can ensure alignment of objectives across company departments, accelerate development timelines, minimize development risks, and eventually lead to an optimal product. A TPP is particularly important Pevonedistat manufacturer for parenteral products due to the need for administration devices, the variety of possible end users (nurses, patients, pharmacists, and physicians), and requirements specific to sterile products. This manuscript describes key components of a TPP from a formulation development perspective and provides guidance on practical issues common to parenteral products.”
“Smith-Magenis syndrome (SMS) is a complex neurobehavioural disorder characterised by intellectual disability, self-injurious behaviours, sleep disturbance, obesity, and craniofacial and skeletal anomalies.

Future directions include the investigation of newer chemotherapy regimens, the addition of targeted therapies, and the use of position emission tomography to provide an early assessment of response.”
“To evaluate whether

an interdisciplinary intervention program on lifestyle results in better quality of life (QoL) and lower frequencies of depression and binge eating disorder (BED) in individuals at risk for type 2 diabetes mellitus.

A total of 177 individuals (32.2% men, age 55.4 +/- A 12.5 years) at risk for diabetes were buy ON-01910 allocated to a 9-month traditional (TI) or intensive interdisciplinary intervention (II) on dietary habits and physical activity including psychoeducative groups. They were submitted to questionnaires and clinical and laboratory examinations. Predictors of non-adherence were analyzed by logistic regression.

Only individuals submitted to II had Histone Methyltransf inhibitor blood pressure and plasma glucose levels reduced. Frequencies of depression reduced in both interventions but of BED only in II (28.0-4.0%, P < 0.001). Increments in the scores of SF-36 domains (physical functioning: 11.1 +/- A 14.0 vs. 5.3 +/- A 13.0, role-emotional: 20.4 +/- A 40.2 vs. 6.2 +/- A

43.8, P = 0.05) were greater in the II than in TI, respectively. Changes in SF-36 correlated with decreases in anthropometry, blood pressure and glucose levels, depression and BED scores. Male gender was independently associated with non-adherence to the II.

In addition to metabolic benefits, an interdisciplinary approach may induce desirable extrametabolic effects, favoring the control of psychiatric disorders and improving

the QoL of individuals at risk for diabetes.”
“New methods are needed to eradicate or prevent Chlamydia trachomatis infections. Blockade of epithelial membrane protein 2 (EMP2) by genetic silencing or neutralizing polyclonal antibody reduced chlamydial infectivity in vitro. This study tests the prediction that recombinant anti-EMP2 diabody could reduce early chlamydial infection of the genital tract in vivo. In a murine infection model, pretreatment with anti-EMP2 diabody, as compared with control diabody, significantly reduced bacterial load, tissue production of inflammatory https://www.selleckchem.com/products/dibutyryl-camp-bucladesine.html cytokines, recruitment of polymorphonuclear leukocytes, and local tissue inflammation. These findings support EMP2 as a potential preventative and therapeutic target for genital chlamydial infection.”
“Adenocarcinoma arising in the setting of Barrett’s esophagus has the fastest increasing incidence of any malignancy in the United States. Advanced esophageal cancer carries an overall poor prognosis with most patients presenting with incurable disease. Over the past several years, new options have been introduced for the purpose of providing palliative therapy to improve quality of life.

069, ANOVA). In addition, the surviving fraction values obtained for MF-exposed samples were in all cases less than for the controls, being the P value obtained for the whole set of MF-treated strains close to significance (P=0.066, Student’s t-test). In contrast, the cell cycle evolution and the DNA pattern obtained for wt and the mutant strains were not altered after exposure to MF.

Conclusions: The data presented in the current report show that the applied MF (2.45 mT, sinusoidal 50 Hz, 96 h) induces alterations in the growth and survival of S. cerevisiae strains deficient

selleck screening library in DNA strand breaks repair. In contrast, the MF treatment does not induce alterations in the cell cycle and does not cause DNA damage.”
“From the five genes which code for cytosolic fructose 1,6-bisphosphate

aldolases in Arabidopsis thaliana L, the cDNA clone of cAld2 (At2g36460), was heterologously expressed in E. coli and incubated under various oxidizing and reducing conditions. Covalent binding of a GSH moiety to the enzyme was shown by incorporation of biotinylated GSH (BioGEE) and by immunodetection with monoclonal anti-GSH serum. Nitrosylation after incubation with GSNO or SNP was demonstrated using the biotin-switch assay. Mass-spectrometry analysis showed glutathionylation and/or nitrosylation at two different cysteine residues: GSH was found to be attached to C68 and C173, while the nitroso-group was incorporated only into C173. Non-reducing SDS-PAGE conducted with purified wild-type and various Cysmutant proteins revealed the presence of disulfide bridges in the oxidized enzyme, as described for rabbit SYN-117 chemical structure https://www.selleckchem.com/products/ipi-145-ink1197.html muscle aldolase. Incubation of the purified enzyme with GSSG (up to 25 mM) led to partial and reversible inactivation of enzyme activity; NADPH, in the presence of the components of the cytosolic NADP-dependent thioredoxin system, could reactivate the aldolase as did DTT. Total and irreversible inactivation occurred with low concentrations (0.1 mM) of nitrosoglutathione

(GSNO). Inactivation was prevented by co-incubation of cAld2 with fructose-1,6-bisphosphate (FBP). Nuclear localization of cAld2 and interaction with thioredoxins was shown by transient expression of fusion constructs with fluorescent proteins in isolated protoplasts. (C) 2011 Elsevier Masson SAS. All rights reserved.”
“We present the fabrication steps and the properties of ramp-edge Josephson junctions using electron-doped high T(c) cuprate Pr(2-x)Ce(x)CuO(4) (PCCO) for the electrodes and the barrier. The superconducting properties of these PCCO junctions are similar to those fabricated from the hole-doped high temperature superconductors. For superconducting electrodes with x 0: 13, 0: 15 or 0: 17 and a nonsuperconducting barrier with x = 0: 05 and thicknesses as large as 35 nm, we observe large critical current densities, periodic oscillations of critical current I(c) in a magnetic field and Shapiro steps.

01- or 0.1-mL inoculum was used. There was no significant difference in the amount of shedding between mammary glands infected with isolates in genotypic cluster 1 or 2. No consistent shedding patterns were identified among

or within cows. There was a significant difference in mammary gland linear score and test day (composite) linear score between mammary glands infected with isolates in genotypic clusters 1 and 2.

Conclusions and Clinical Relevance-S aureus was shed consistently in cows with naturally occurring intramammary infection in cows, and regardless of the pulsotype, variations in the amount of S aureus shedding had no significant effect on the ability to detect S aureus with a 0.1-mL inoculum.”
“Previous LY3039478 cell line reports on pernicious anemia treatment suggested that high folic acid intake adversely influences the natural history of vitamin B-12 deficiency, which affects Selleckchem Tipifarnib many elderly

individuals. However, experimental investigation of this hypothesis is unethical, and the few existing observational data are inconclusive. With the use of data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES), we evaluated the interaction between high serum folate and low vitamin B-12 status [ie, plasma vitamin B-12, 148 pmol/L or methylmalonic acid (MMA). 210 nmol/L] with respect to anemia and cognitive impairment. With subjects having both plasma folate <= 59 nmol/L and normal vitamin B-12 status as the referent category, odds ratios for the prevalence of anemia compared QNZ with normal hemoglobin concentration and impaired compared with unimpaired cognitive function were 2.1 (95% CI: 1.1, 3.7) and 1.7 (95% CI: 1.01, 2.9), respectively, for those with low vitamin B-12 status but normal serum folate and 4.9 (95% CI: 2.3, 10.6) and 5.0 (95% CI: 2.7, 9.5), respectively, for those with low vitamin B-12

status and plasma folate > 59 nmol/L. Among subjects with low vitamin B-12 status, mean circulating vitamin B-12 was 228 pmol/L for the normal-folate subgroup and 354 pmol/L for the high-folate subgroup. We subsequently showed increases in circulating homocysteine and MMA concentrations with increasing serum folate among NHANES participants with serum vitamin B-12, 148 pmol/L, whereas the opposite trends occurred among subjects with serum vitamin B-12 >= 148 pmol/L. These interactions, which were not seen in NHANES III before fortification, imply that, in vitamin B-12 deficiency, high folate status is associated with impaired activity of the 2 vitamin B-12-dependent enzymes, methionine synthase and MMA-coenzyme A mutase. Am J Clin Nutr 2009; 89(suppl): 702S-6S.”
“This study is focused on the investigation of moisture uptake properties of chitosan films. The GAB isotherm model is found to fit well to the experimental moisture uptake data obtained at 10, 25, and 37 C. The water vapor permeability is found to increase with temperature.

SummaryThe effect of treatment on the severity of common cold symptoms cannot be accurately assessed with current study designs. Wnt inhibitor In the absence of convincing evidence of efficacy, treatment of young children with symptomatic therapies cannot be recommended. Preliminary data suggest a small, beneficial effect of probiotics for the prevention of common cold illness.”
“Objectives: The Agency

for Healthcare Research and Quality (AHRQ) Effective Health Care Program conducts systematic reviews of health-care topics nominated by stakeholders. Topics undergo refinement to ensure relevant questions of appropriate scope and useful reviews. Input from key informants, experts, and a literature scan informs changes in the nominated topic. AHRQ convened a work group to assess approaches and develop recommendations

for topic refinement.

Study Design and Setting: Work group members experienced in topic refinement generated a list of questions and guiding principles relevant to the refinement process. They discussed each issue and reached agreement on recommendations.

Results: Topics should address important health-care questions or dilemmas, consider stakeholder priorities and values, reflect the state of the science, check details and be consistent with systematic review research methods. Guiding principles of topic refinement are fidelity to the nomination, relevance, research feasibility, responsiveness to stakeholder inputs, reduced investigator bias, transparency, and suitable scope. Suggestions for stakeholder engagement, synthesis of input, and reporting are discussed. Refinement decisions require judgment and balancing guiding principles. Variability in topics precludes a prescriptive approach.

Conclusion: Accurate, rigorous, and useful systematic reviews require well-refined topics. These guiding principles and methodological recommendations may help investigators refine topics for reviews. (C) 2014 Elsevier Inc. All rights reserved.”
“Identifying relevant subgroups in patients with low back pain (LBP) is considered important to guide physical therapy practice and to improve outcomes. learn more The aim of the present study

was to assess the cost-effectiveness of a modified version of Delitto’s classification-based treatment approach compared with usual physical therapy care in patients with sub-acute and chronic LBP with 1 year follow-up.

All patients were classified using the modified version of Delitto’s classification-based system and then randomly assigned to receive either classification-based treatment or usual physical therapy care. The main clinical outcomes measured were; global perceived effect, intensity of pain, functional disability and quality of life. Costs were measured from a societal perspective. Multiple imputations were used for missing data. Uncertainty surrounding cost differences and incremental cost-effectiveness ratios was estimated using bootstrapping.

Methods: We examined changes in nutritional intake using data acquired from a community-based stroke care system. There were 334 stroke patients who were discharged from our acute care hospital and transferred to rehabilitation hospitals with tube feeding. We examined the relationship between the initial bedside swallowing assessment and the method of nutrition delivery at discharge from a rehabilitation hospital. We also calculated LY2090314 mouse the functional independent measure (FIM) to examine the relationship between activities of daily living and nutritional intake. Results: There were 291 patients

on oral intake and 43 on enteral feeding at discharge from a rehabilitation hospital. Patients with enteral feeding were older than patients with oral intake (69.4 +/- 11.4 v 75.2 +/- 9.9 years; P = .0016). The enteral feeding group also had lower FIM gain (27.5 +/- 28.3 v 16.5 +/- 23.5; P = .0161) and FIM efficiency

(1.10 +/- 1.24 v 0.65 +/- 1.26; P = .0270) at the acute care hospital. Conclusions: Age, FIM gain, and FIM efficacy in the acute care hospital reliably predicted the long-term prognosis of eating selleck chemicals llc and swallowing disability.”
“The aim of this study was to histologically and histometrically evaluate the influence of repeated adjunctive antimicrobial photodynamic therapy (aPDT) on bone loss (BL) in furcation areas in rats. Periodontitis was induced by placing a ligature around the mandibular molar in 75 rats. The animals were divided into five groups: the SS group was treated with saline solution (SS); the SRP group received scaling and root planing (SRP); the aPDT1 group received SRP as well as toluidine blue (TBO) and low-level laser therapy (LLLT; InGaAlP, 660 SHP099 in vivo nm; 4.94 J/cm(2)/point) postoperatively

at 0 h; the aPDT2 group received SRP as well as TBO and LLLT postoperatively at 0, 24, 28, and 72 h; and the aPDT3 group received SRP, TBO, and LLLT postoperatively at 0, 48, 96, and 144 h. The area of BL in the furcation region of the molar was histometrically analyzed. Data were analyzed statistically (P < 0.05). Animals treated with a single episode of aPDT showed less BL at days 7 and 30 than those who received only SRP treatment. No significant differences were found among the aPDT groups (P > 0.05). Repeated aPDT did not improve BL reduction when compared to a single episode of aPDT.”
“Objective: To evaluate the smart algorithm in speed and reliability of threshold estimation compared with the algorithm available in the standard fitting software and to evaluate the possibility of using programs based on the smart algorithm instead of programs derived from behavioral measures.

Patients: Twenty subjects unilaterally implanted with a CII Bionic Ear or HiRes90K device.

Interventions: Neural response imaging thresholds (t(NRI)) were measured using both the smart approach within the Research Studies Platform for Objective Measures and the SoundWave fitting software.

Complication rate was 18.9 % in the first period and 3 % in the last. We reoperated on 9 % of patients in two early periods and none in the last. Mortality rate was 2, 0.85, 0.47 and 0 % in the four periods. Teams that are just at the beginning of their experience in bariatric surgery in order to avoid complications and deal with better long-term results.”
“OBJECTIVE: The aim of this study is to compare thoracoscopic mobilization of the oesophagus in the lateral Androgen Receptor Antagonist molecular weight decubitus position and the semiprone position and to identify potential differences

between the two techniques.

METHODS: A retrospective review of a prospectively maintained oesophagectomy database identified 150 patients undergoing combined thoracoscopic and laparoscopic oesophagectomy (TLO). Of these, 90 cases underwent PFTα price thoracoscopic oesophageal mobilization in the left lateral decubitus position. The remaining 60 cases underwent thoracoscopic oesophageal mobilization in the semiprone position.

RESULTS: There were no differences in the clinicopathological factors and tumour characteristics between the two groups. There was no significant difference

in the blood loss, operation time, the incidence of conversion, length of hospital stay or in the number of retrieved mediastinal and abdominal nodes between the two groups. There was no significant difference with regard to the incidence of respiratory complications, anastomotic leaks, vocal cord palsy, chylothorax, delayed gastric emptying, arrhythmia and intestinal obstruction between the two groups.

CONCLUSION: The semiprone and lateral decubitus positions each have their inherent advantages and disadvantages. LY3039478 in vivo Our initial experience confirmed that while the semiprone position is associated with superior surgical ergonomics and better exposure of the posterior mediastinum, there is no convincing evidence that semiprone thoracoscopic oesophagectomy is superior to the left lateral decubitus positioning with respect to the major surgical outcomes and oncological clearance.”
“Uterine

artery embolization (UAE) is still regarded by most gynaecologists as contraindicated for women with symptomatic fibroids and otherwise unexplained infertility. For such patients, myomectomy is the usual option. We performed UAE as treatment of menorrhagia in an infertile woman with multiple subserosal and intramural fibroids who had previously failed multiple myomectomy. UAE resulted in durable symptom relief and substantial reduction of the uterine and fibroid size. The patient conceived spontaneously 20 months after UAE and progressed through pregnancy uneventfully. At 38 weeks of gestation, she underwent elective cesarean section and delivered a normal, healthy, 3180-g fetus without complications.

We observed that the rotavirus peak shifted gradually from January to April (winter to early spring) during 17 seasons and the GIP[8] combination was the most predominant genotype in the last 28 years in Japan.”
“Background: Assessment exposure and immunity to malaria is an important step in the fight against the disease. Increased malaria infection in non-immune travellers under anti-malarial chemoprophylaxis, as well as the implementation

of malaria elimination programmes in endemic countries, raises new issues that pertain to these processes. Notably, monitoring malaria immunity has become more difficult in individuals showing low antibody (Ab) responses or taking medications against the Plasmodium falciparum blood stages. Commonly available techniques in malaria seroepidemiology PARP phosphorylation have limited sensitivity, both CH5424802 manufacturer against pre-erythrocytic, as against blood stages of the parasite. Thus, the aim of this study was to develop a sensitive tool to assess the exposure to malaria or

to bites from the vector Anopheles gambiae, despite anti-malarial prophylactic treatment.

Methods: Ab responses to 13 pre-erythrocytic P. falciparum-specific peptides derived from the proteins Lsa1, Lsa3, Glurp, Salsa, Trap, Starp, CSP and Pf11.1, and to 2 peptides specific for the Anopheles gambiae saliva protein gSG6 were tested. In this study, 253 individuals from three Senegalese areas with different transmission intensities and 124 European travellers exposed to malaria during a short period of time were included.

Results: The multiplex assay AZD7762 was optimized for most but not all of the antigens. It was rapid, reproducible and required a small volume of serum. Proportions of Ab-positive individuals, Ab levels and the mean number of antigens (Ags) recognized by each individual increased significantly with increases in the level of malaria exposure.

Conclusion: The multiplex assay developed here provides a useful tool to evaluate immune responses to multiple Ags in large populations,

even when only small amounts of serum are available, or Ab titres are low, as in case of travellers. Finally, the relationship of Ab responses with malaria endemicity levels provides a way to monitor exposure in differentially exposed autochthonous individuals from various endemicity areas, as well as in travellers who are not immune, thus indirectly assessing the parasite transmission and malaria risk in the new eradication era.”
“The aim of this study was to assess the correlation between the estimated adherence of HIV-1 infected patients with antiretroviral (ARV) therapy failure and drug-resistant mutations. We studied 40 patients with virological and immunological ARV-therapy failure. In order to assess the adherence of patients we used the SERAD questionnaire. Genomic sequencing of the HIV-1 pol gene was performed. 100% adherence was reported by 27 patients (67.5%) (adherent patients).

5-6] h in group

NB, 18 [6-18] h in group S and 18 [18-18] h in group B (P-0.000). The number of demands of rescue analgesia was significantly less in group B 0 [0-0.25], 0 [0-2] in S group compared to group NB 3 [3-3] (P-0.000). The parental satisfaction was good in patients who received block and poor in group NB.

Conclusion:

Palatal block is technically simple, safe and effectively provides postoperative analgesia with good parental satisfaction. Injection of saline also selleck products produced palatal nerve block; however, the effect was not consistent.”
“Background: Computer-based clinical decision support aims to improve the quality of patient care. The utility of decision support for improving blood pressure control in hemodialysis patients is unknown.

Methods: This was a nonrandomized controlled trial of adult patients receiving chronic in-center hemodialysis during the period of April 1, 2005, to September 30, 2006, in 1 of the 2 major university-based renal programs in Alberta, Canada. Physicians in the intervention center were provided with twice-monthly audits and printed JNK-IN-8 management suggestions based on guideline-recommended blood pressure targets. The same data were available to physicians in the control group but without audit and feedback decision support.

Results: Eight hundred and thirty hemodialysis patients were receiving dialysis treatment at the time the study was initiated. Preintervention and postintervention blood

pressure data were available for GSK J4 mouse 361 patients. The primary outcome, the proportion of postdialysis systolic blood pressures at target over 12 months, did not differ between the intervention and the control programs (unadjusted odds ratio 0.59; 95% confidence interval [95% CI], 0.34-1.02, p = 0.06; adjusted odds ratio 0.62; 95% CI, 0.35-1.11, p = 0.11). There was no significant difference between the intervention

and control groups in other measures of blood pressure such as the mean change in postdialysis systolic blood pressures (unadjusted mean difference 4 mm Hg, 95% CI, -1 to 9, p = 0.36; adjusted mean difference 2 mm Hg, 95% CI, -1 to 5, p = 0.19).

Conclusions: In this population of chronic hemodialysis patients, a computer-based clinical decision support system was not associated with improved blood pressure control.”
“P>Background:

The recommendations for perioperative maintenance fluid in children have been adapted from hypotonic to isotonic electrolyte solutions with lower glucose concentrations (1-2.5% instead of 5%) to avoid hyponatremia or hyperglycemia.

Objective:

The objective of this prospective animal study was to determine the margin of safety of a novel isotonic-balanced electrolyte solution with 1% glucose (BS-G1) in comparison with normal saline with 1% glucose (NS-G1) in the case of accidental hyperhydration with a focus on acid-base electrolyte balance, glucose concentration, osmolality and intracranial pressure in piglets.

Methods:

Ten piglets (bodyweight 11.

Methods: Patients referred for primary PCI and TH between July 2004 and April 2011 were identified from the University of Ottawa Heart Institute STEMI database. The primary endpoint was survival to hospital discharge with sufficient neurologic recovery to enable discharge home.

Results: Among 2467 consecutive patients selleck screening library referred for primary PCI, we identified

50 patients treated with TH following OHCA. Forty-nine underwent PCI, of which 47 (96%) received a stent. Median door-to-balloon time was 113 min (IQR 91-151). Patients with good neurologic recovery were younger, mean 51 +/- 9 years versus 64 +/- 12, p < 0.001, and had higher baseline creatinine clearance, 70 +/- 19 mL/min/1.73 m(2) versus 53 +/- 23 mL/min/1.73 m(2), p = 0.007. The primary

endpoint of survival with sufficient neurologic recovery to enable discharge home was reached in 30 patients (60%). Four survivors required levels of assistance that precluded discharge home.

Conclusions: Therapeutic hypothermia in conjunction with primary PCI is associated with a favorable neurologic outcome in the majority of STEMI patients surviving OHCA. Our results suggest that TH is an important adjunctive therapy for STEMI Selleckchem EGFR inhibitor patients suffering OHCA. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Objective: Alterations in joint mechanics selleck products can cause osteoarthritis, which results in degeneration of both cartilage and bone tissue. The objective of this work is to measure changes in the laxity of the mouse knee joint after destabilisation of the medial meniscus (DMM) and to visualise and quantify the resulting three-dimensional changes in the bone and cartilage.

Methods: Skeletally mature C57Bl6 male mice underwent DMM surgery in the right leg. Animals were sacrificed immediately 0 weeks (n = 15), 4 weeks (n = 11) or 8 weeks (n = 12) after surgery. For the 0-week group, the anterior posterior (AP) and varus valgus laxity of the DMM limb were compared to the contralateral limb. For 4 and 8-week groups,

tibiae were scanned with micro-computed tomography (mu ACT) to quantify and visualise bone changes and with confocal scanning laser microscopy (CSLM) to measure changes in cartilage.

Results: Laxity testing measured an increase in AP range of motion, particularly in the anterior direction. The DMM limbs showed a decrease in epiphyseal trabecular bone at 8 weeks and a decrease in cartilage volume, primarily on the posterior medial plateau, compared to the contralateral limb. Significant bone remodelling was observed at the periphery of the joint and in severe cases, osteolysis extended through the growth plate.

Conclusion: Multimodal imaging allowed quantifiable 3D assessment of bone and cartilage and indicated extensive changes in the tissues.